Description

Description

Consult the definitive resource in rheumatology for an in-depth understanding of scientific advances as they apply to clinical practice. Masterfully edited by Drs. Gary S. Firestein, Ralph C. Budd, Sherine E. Gabriel, Iain B. McInnes, and James R. O’Dell, and authored by internationally renowned scientists and clinicians in the field, Kelley and Firestein’s Textbook of Rheumatology, 10th Edition, delivers the knowledge you need for accurate diagnoses and effective patient care. From basic science, immunology, anatomy, and physiology to diagnostic tests, procedures, and specific disease processes, this state-of-the-art reference provides a global, authoritative perspective on the manifestations, diagnosis and treatment of rheumatic diseases.

Key Features

• An ideal balance of the basic science you need to know and how to apply that information to clinical practice.
• An integrated chapter format allows you to review basic science advances and their clinical implications in one place and get dependable, evidence-based guidance for the full range of rheumatologic diseases and syndromes.
• Videos online demonstrate the complete musculoskeletal exam, including abnormal findings and the arthroscopic presentation of diseased joints.

New to this Edition

• New content on the latest diagnostic perspectives and approaches to therapy, including five brand-new chapters: Metabolic Regulation of Immunity, Principles of Signaling, Research Methods in the Rheumatic Diseases, Novel Intracellular Targeting Agents, and IgG4-Related Diseases.
• New and expanded chapter topics on small molecule treatment, biologics, biomarkers, epigenetics, biosimilars, and cell-based therapies.
• More schematic diagrams clearly summarize information and facilitate understanding.

Contents

1 Biology of the Normal Joint
2 Synovium
3 Cartilage and Chondrocytes
4 Biology, Physiology, and Morphology of Bone
5 Muscle: Anatomy, Physiology, and Biochemistry
6 Biomechanics
7 Tissue Engineering
8 Proteinases and Matrix Degradation
9 Dendritic Cells
10 MACROPHAGES
11 Neutrophils
12 T Lymphocytes
13 B Cells
14 Fibroblasts and Fibroblast-like Synoviocytes
15 Mast Cells
16 Platelets and Rheumatic Diseases
17 Innate Immunity
18 ADAPTIVE IMMUNITY and Organization of Lymphoid Tissues
19 Autoimmunity
20 METABOLIC REGULATION IN IMMUNITY
21 Genetics of Rheumatic Diseases
22 Epigenetics of rheumatic diseases
23 Complement System
24 Prostaglandins, Leukotrienes, and Related Compounds
25 Cell Recruitment and Angiogenesis
26 Cytokines
27 PRINCIPLES OF SIGNALING
28 Cell Survival and Death in Rheumatic Diseases
29 Animal Models of Rheumatic Diseases
30 Neural regulation of Pain and Inflammation
31 RESEARCH METHODS IN THE RHEUMATIC DISEASES
32 BURDEN OF THE RHEUMATIC DISEASE
33 Assessment of Health Outcomes IN RHEUMATIC DISEASES
34 Biologic Markers
35 Occupational and Recreational MSK Disorders
36 Cardiovascular Risk in Rheumatic Disease
37 Cancer Risk in Rheumatic Diseases
38 Introduction to Physical Medicine, Physical Therapy and Rehabilitation
39 Pregnancy and Rheumatic Diseases
40 History and Physical Examination of the Musculoskeletal System
41 EVALUATION AND DIFFERENTIAL DIAGNOSIS OF Monoarticular Arthritis
42 EVALUATION AND DIFFERENTIAL DIAGNOSIS OF Polyarticular Arthritis
43 The Skin and Rheumatic Diseases
44 The Eye and Rheumatic Diseases
45 Neck Pain
46 Shoulder Pain
47 Low Back Pain
48 Hip and Knee Pain
49 Ankle and Foot Pain
50 Hand and Wrist Pain
51 Temporomandibular Joint Pain
52 Fibromyalgia
53 Synovial Fluid Analysis, Synovial Biopsy, and Synovial Pathology
54 Arthrocentesis and Injection of Joints and Soft Tissue
55 Antinuclear Antibodies
56 Autoantibodies in rheumatoid arthritis
57 Acute Phase Reactants
58 Imaging Modalities in Rheumatic Disease
59 Prostanoid Biology and its Therapeutic Targeting
60 Glucocorticoid Therapy
61 Traditional DMARDS: Methotrexate, Leflunomide, Sulfasalazine, and Hydroxychloroquine and Combination Therapies
62 TRADITIONAL Immunoregulatory Drugs
63 Anticytokine Therapies
64 Cell Targeted Biologics
65 NOVEL INTRACELLULAR TARGETING AGENTS
66 Urate Lowering Therapy
67 Analgesic Agents in Rheumatic Diseases
68 Nutrition and Rheumatic Disease
69 Etiology and Pathogenesis of Rheumatoid Arthritis
70 Clinical Features of Rheumatoid Arthriti
71 Treatment of Rheumatoid Arthritis
72 Early Synovitis and Early Undifferentiated Arthritis
73 Sjogren’s Syndrome
74 Etiology and Pathogenesis of Spondyloarthropathies
75 Ankylosing Spondylitis
76 Undifferentiated Spondyloarthritis and Reactive Arthritis
77 Psoriatic Arthritis
78 Enteropathic Arthritis
79 Etiology and Pathogenesis of SLE
80 Clinical Features of SLE
81 Treatment of SLE
82 Antiphospholipid Syndrome
83 Etiology and Pathogenesis of Scleroderma
84 Clinical Features and Treatment of Scleroderma
85 Inflammatory Diseases of Muscle and Other Myopathies
86 Overlap Syndromes
87 Classification and Epidemiology of Systemic Vasculitis
88 Giant Cell Arteritis, Polymyalgia Rheumatica, and Takayasu’s Arteritis
89 Antineutrophil Cytoplasmic Antibody-Associated Vasculitis
90 Polyarteritis and Related Disorders
91 Immune Complex-Mediated Small Vessel Vasculitis
92 Isolated Angiitis of the Nervous System
93 Behcet’s Disease
94 Etiology and Pathogenesis of Gout and Hyperuricemia
95 Clinical Features and Treatment of Gout
96 Calcium Crystal Diseases: Calcium Pyrophosphate Dihydrate and Basic Calcium Phosphate
97 Familial Autoinflammatory Syndromes
98 Etiology and Pathogenesis of Osteoarthritis
99 Clinical Features of Osteoarthritis
100 Treatment of Osteoarthritis
101 Metabolic Bone Disease
102 Proliferative Bone Disease
103 Osteonecrosis
104 Relapsing Polychondritis
105 Heritable Diseases of Connective Tissue
106 Etiology and Pathogenesis of Juvenile Idiopathic Arthritis
107 Treatment of Juvenile Inflammatory Arthritis
108 SLE, Juvenile Dermatomyositis, Scleroderma and Vasculitis
109 Bacterial Arthritis
110 Lyme Disease
111 Mycobacterial Infections of Bones and Joints
112 Fungal Infections of Bones and Joints
113 Rheumatic Manifestations of HIV Infection
114 Viral Arthritis
115 Rheumatic Fever and Post-Streptococcal Arthritis
116 Amyloidosis
117 Sarcoidosis
118 Hemachromotosis
119 Hemophilic Arthropathy
120 Rheumatic Manifestations of Hemoglobinopathies
121 IgG4-RELATED DISEASES
122 Arthritis Accompanying Endocrine and Metabolic Disorders
123 Musculoskeletal Syndromes Associated with Malignancy
124 Tumors and Tumor-like Lesions of Joints and Related Structures