Description

Description

Part of the highly regarded Diagnostic Pathology series, Diagnostic Pathology: Blood and BoneMarrow, second edition includes today’s most recent knowledge on the latest finds in thissubspecialty. New chapters focus on current molecular insights into the pathogenesis of familialdisorders and neoplasms, ensuring pathologists, hematopathologists, hematologists, and oncologists alike can deliver the most up-to-date diagnoses possible. Concise, bulleted text coupled with extensive illustrations makes this succinct yet comprehensivereferenceideal for clinical use.

Key Features

• Expert Consult eBook version included, which allows you to search all of the text, figures, and references from the book on a variety of devices
• Includes an introductory chapter on the basics of hematopathology, such as a review of normal peripheral blood and bone marrow histology, flow charts of hematopoiesis, photomicrographs of thevarious stages of each lineage, and descriptions of the common stains used in hematopathology
• Multiple new chapters focus on current molecular insights into the pathogenesis of familial disorders and neoplasms
• Features a new chapter on familial leukemia propensity disorder
• Content covers many of today’s hot topics, including likely new WHO 2016 entities, novel genetic subtypes of acute lymphoblastic leukemia, multiple new lymphoma subtypes, clinical practiceguidelines for diagnosis of acute leukemias, and hematologic problems of the elderly
• Pinpoints important elements in the diagnosis of benign and neoplastic disorders
• Clearly delineates numerous genetic disorders often found in blood and bone marrow
• Ideal for trainees seeking basic information as well as experienced practitioners in need of a brief refresher

Kathryn Foucar, MD

Vice Chair of Clinical Affairs, Department of Pathology, The University of New Mexico Health Science Center, Albuquerque, New Mexico

Contents

Part I: Introduction

• Hematopoiesis and Bone Marrow Histology
• Bone Marrow Examination and Techniques
• Bone Marrow Reporting
• Overview of Constitutional and Acquired Bone Marrow Disorders

Part II: Anemia

• Overview of Anemia

SECTION 1: ACQUIRED ANEMIAS

• Iron Deficiency Anemia
• Autoimmune Hemolytic Anemias
• Alloimmune Hemolytic Anemia and Hemolytic Disease of Newborn
• Microangiopathic Hemolytic Anemia
• Megaloblastic Anemia
• Acquired Nonneoplastic Sideroblastic Anemia
• Alcoholism-Associated Anemia
• Anemia in the Elderly
• Copper Deficiency-Associated Anemia
• Acquired Red Cell Aplasia
• Transient Erythroblastopenia of Childhood
• Parvovirus-Induced Red Cell Aplasia
• Paroxysmal Nocturnal Hemoglobinuria
• Acquired Aplastic Anemia

SECTION 2: CONSTITUTIONAL ANEMIAS

• Thalassemia
• Sickle Cell Anemia
• Pyruvate Kinase Deficiency
• Hereditary Spherocytosis
• Hereditary Elliptocytosis, Including Hereditary Pyropoikilocytosis
• Diamond-Blackfan Anemia
• Fanconi Anemia
• Congenital Dyserythropoietic Anemia
• Congenital Sideroblastic Anemia
• Congenital Megaloblastic Anemia

Part III: Erythrocytosis

SECTION 1: CONSTITUTIONAL

• Congenital Erythrocytosis

SECTION 2: ACQUIRED

• Acquired Erythrocytosis

Part IV: Benign Leukocyte Disorders in Blood and Bone Marrow

• Overview of Benign Leukocyte Disorders in Blood and Bone Marrow
• Pancytopenia
• Neutropenia
• Neutrophilia
• Monocytosis
• Eosinophilia
• Basophilia
• Lymphocytosis
• Lymphopenia, Constitutional and Acquired
• Plasmacytosis of Bone Marrow
• Hematogones in Bone Marrow
• Lymphoid Aggregates in Bone Marrow
• Granulomas in Bone Marrow

Part V: Constitutional Granulocytic Disorders

SECTION 1: CONSTITUTIONAL NEUTROPENIAS

• Severe Congenital Neutropenia and Cyclic Neutropenia
• Shwachman-Diamond Syndrome
• Chediak-Higashi Syndrome
• Myelokathexis in WHIM Syndrome

SECTION 2: CONSTITUTIONAL NEUTROPHIL ANOMALIES

• Pelger-Huet Anomaly
• MYH9-Related Disorders
• Selected Lysosomal Storage Diseases With Abnormal Leukocyte Granulation

Part VI: Megakaryocytic Disorders

• Overview of Megakaryocytic Disorders

SECTION 1: ACQUIRED PLATELET DISORDERS WITH THROMBOCYTOPENIA

• Immune-Mediated Thrombocytopenia
• Hemolytic-Uremic Syndrome
• Thrombotic Thrombocytopenic Purpura
• Pregnancy-Associated Thrombocytopenia

SECTION 2: CONSTITUTIONAL PLATELET DISORDERS WITH THROMBOCYTOPENIA

• Thrombocytopenia Absent Radius Syndrome
• Congenital Amegakaryocytic Thrombocytopenia
• Gray Platelet Syndrome
• Wiskott-Aldrich Syndrome-Related Disorders
• Congenital Thrombotic Thrombocytopenic Purpura

SECTION 3: THROMBOCYTOSIS

• Thrombocytosis

Part VII: Infection

• Overview of Infection
• Hantavirus Pulmonary Syndrome
• Human Immunodeficiency Virus
• Infectious Mononucleosis Syndromes (Epstein-Barr Virus, Cytomegalovirus)
• Parvovirus B19 Infection
• Bacterial Infections, Blood and Bone Marrow Features
• Fungal Infections, Blood and Bone Marrow Features
• Helminthic Infections
• Malaria
• Other Protozoan Infections

Part VIII: Miscellaneous Nonneoplastic Disorders and Conditions

• Overview and Classification of Hemophagocytic Disorders in Bone Marrow
• Hematologic Manifestations of Collagen Vascular Disorders
• Hematologic Manifestations of Chronic Renal Disorders
• Lysosomal Storage Diseases With Predominantly Histiocytic Storage
• Other Pregnancy-Associated Hematologic Disorders
• Gelatinous Transformation and Other Bone Marrow Stromal Disorders
• Crystals in Bone Marrow
• Bone Abnormalities in Bone Marrow Specimens

Part IX: Myeloid Neoplasms

• Overview and Classification of Myeloid Neoplasms
• Protocol for the Examination of Specimens From Patients With Hematopoietic Neoplasms Involving Bone Marrow
• Clinical Practice Guidelines for Initial Work-Up of Acute Leukemia

SECTION 1: MYELOPROLIFERATIVE NEOPLASMS

• Overview of Myeloproliferative Neoplasms
• Chronic Myelogenous Leukemia, BCR/ABL1+
• Chronic Neutrophilic Leukemia
• Polycythemia Vera
• Primary Myelofibrosis
• Essential Thrombocythemia
• Chronic Eosinophilic Leukemia, Not Otherwise Specified
• Systemic Mastocytosis
• Mast Cell Leukemia
• Myeloproliferative Neoplasm, Unclassifiable

SECTION 2: MYELOID AND LYMPHOID NEOPLASMS WITH EOSINOPHILIA AND ABNORMALITIES OF PDGFRA, PDGFRB, AND FGFR1

• Myeloid and Lymphoid Neoplasms With PDGFRA Rearrangement
• Myeloid Neoplasms With PDGRFB Rearrangments
• Myeloid and Lymphoid Neoplasms With FGFR1 Abnormalities

SECTION 3: MYELODYSPLASTIC & MYELOPROLIFERATIVE NEOPLASMS

• Overview of Myelodysplastic/Myeloproliferative Neoplasms
• Chronic Myelomonocytic Leukemia
• Atypical Chronic Myeloid Leukemia, BCR/ABL1-
• Juvenile Myelomonocytic Leukemia
• RARS-T
• Myelodysplastic/Myeloproliferative Neoplasms, Unclassifiable

SECTION 4: MYELODYSPLASTIC SYNDROMES

• Overview and Classification of Myelodysplastic Syndromes
• Myelodysplasia With Single Lineage Dysplasia
• Myelodysplasia With Ring Sideroblasts
• Myelodysplasia With Multilineage Dysplasia
• Myelodysplasia With Increased Blasts
• Myelodysplastic Syndrome With Isolated del(5q)
• Myelodysplastic Syndrome, Unclassifiable
• Childhood Myelodysplastic Syndrome (Refractory Cytopenia of Childhood)

SECTION 5: ACUTE MYELOID LEUKEMIA

• Overview of Acute Myeloid Leukemia
• Familial AML/MDS
• Acute Myeloid Leukemia With t(8;21)(q22;q22), RUNX1-RUNX1T1
• Acute Myeloid Leukemia With inv(16)(p13.1q22) or t(16;16)(p13.1;q22), CBFB-MYH11
• Acute Promyelocytic Leukemia With t(15;17)(q22;q21), PML-RARA
• Acute Promyelocytic Leukemia With Variant RARA Rearrangement
• Acute Myeloid Leukemia With t(9;11)(p22;q23), MLLT3-MLL
• Additional Genetic Subtypes of Acute Myeloid Leukemia, Including t(6;9), inv(3), t(1;22), Mutated NPM1, Mutated CEBPA
• Acute Myeloid Leukemia With Myelodysplasia- Related Changes
• Therapy-Related Myeloid Neoplasms
• Acute Myeloid Leukemia With Minimal Differentiation
• Acute Myeloid Leukemia Without Maturation
• Acute Myeloid Leukemia With Maturation
• Acute Myelomonocytic Leukemia
• Acute Monoblastic and Monocytic Leukemia
• Acute Erythroid Leukemia
• Acute Megakaryoblastic Leukemia
• Acute Basophilic Leukemia
• Acute Panmyelosis With Myelofibrosis
• Myeloid Proliferations Related to Down Syndrome
• Blastic Plasmacytoid Dendritic Cell Neoplasm

Part X: Acute Leukemias of Ambiguous Lineage

• Acute Undifferentiated Leukemia
• Mixed Phenotype Acute Leukemia

Part XI: Lymphoid Neoplasms

• Overview of Lymphoid Neoplasms
• Protocol for the Examination of Specimens from Patients With Non-Hodgkin Lymphoma/Lymphoid Neoplasms

SECTION 1: B-PRECURSOR NEOPLASMS

• B-Lymphoblastic Leukemia
• Novel Genetic Subtypes of B-Lymphoblastic Leukemia

SECTION 2: T-PRECURSOR NEOPLASMS

• T-Lymphoblastic Leukemia/Lymphoma
• ETP-ALL

SECTION 3: MATURE B-CELL NEOPLASMS

• Overview and Classification of Mature Leukemias, Immunosecretory Lymphomas
• Monoclonal B Lymphocytes
• Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
• B-Cell Prolymphocytic Leukemia
• Splenic B-Cell Marginal Zone Lymphoma
• Hairy Cell Leukemia
• Splenic B-Cell Leukemia, Hairy Cell Leukemia Variant
• Lymphoplasmacytic Lymphoma
• Gamma Heavy Chain Disease
• Monoclonal Gammopathy of Undetermined Significance
• Plasma Cell Myeloma
• Burkitt Leukemia/Lymphoma
• Mantle Cell Lymphoma in Blood and Bone Marrow
• Follicular Cell Lymphoma in Blood and Bone Marrow
• Marginal Zone Lymphoma in Blood and Bone Marrow
• Large Cell Lymphoma in Blood and Bone Marrow
• Other B-Cell Non-Hodgkin Lymphomas Involving Blood and Bone Marrow

SECTION 4: MATURE T/NK-CELL NEOPLASMS

• Overview and Classification of Mature T/NK-Cell Neoplasms
• T-Cell Prolymphocytic Leukemia
• T-Cell Large Granular Lymphocytic Leukemia
• Chronic Lymphoproliferative Disorder of NK Cells
• Aggressive NK-Cell Leukemia
• Adult T-Cell Leukemia
• Mycosis Fungoides/Sézary Syndrome
• Anaplastic Large Cell Lymphoma in Blood and Bone Marrow
• Other T-Cell Non-Hodgkin Lymphomas Involving Blood and Bone Marrow

SECTION 5: HODGKIN LYMPHOMA IN BONE MARROW

• Hodgkin Lymphoma in Bone Marrow, Classic and Lymphocyte Predominant Subtypes
• Protocol for the Examination of Specimens from Patients With Hodgkin Lymphoma
• Part XII: Other Neoplasms Involving Bone Marrow
• Langerhans Cell Histiocytosis in Bone Marrow
• Hemophagocytic Disorders
• Posttransplant Lymphoproliferative Disorders in Bone Marrow
• Metastatic Carcinoma and Sarcoma